Possibility of modification of peripheral blood neutrophils functional activity during chemoradiotherapy in patients with anorectal cancer

Background . Ionizing radiation is an effective antitumor therapy, but it has a serious negative effect on the immune system requiring use of reaction prevention and reduction methods. Neutrophils are sensitive element both in interaction with tumor tissue response to injury. Aim To evaluate functional activity peripheral blood neutrophils by chemiluminescent analysis patients anorectal cancer after radiotherapy. Materials methods The study included 80 cancer. Patients received chemo- radio-therapy 3D conformal radiotherapy therapy under visual control, followed radioprotector without it. Neutrophil determined analysis. Results In found maximum spontaneous induced chemiluminescence acceleration. activation index luminol lower cancer, lucigenin shows no differences control group. low intensity, as well decrease synthesis reactive secondary oxygen species enzymatic systems, likely regulatory intracellular limitations consequence. After treatment, showed number parameters statistically significant Undesirable phenomena associated sodium deoxyribonucleate not detected during subsequent observation period. Conclusion During suggest that ionizing affects them receiving standard chemoradiotherapy. Use chemoradiotherapy leads indirect restoration cellular activity. This confirmed luminol-dependent faster reaching its from group start drug treatment.